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王博
职称:
邮箱:wangbo@cpu.edu.cn
学院:生命科学与技术学院
实验室:江宁校区学院实验楼一期338室
招生学科:生物学、微生物与生化药学、生物与医药
办公室:
个人简历

王博,特聘研究员,博士生导师,课题组长,入选国家级高层次青年人才项目。王博课题组长期致力于开发应用与合成免疫技术,探索免疫系统的工作机理,以此为基础发展编程免疫系统的方法,为疾病治疗提供全新的方案和策略。2016年毕业于美国University of Texas at Austin,2017年进入阿斯利康公司工作,领衔开发的一项抗体工程技术已用于多款药物,2020年进入美国Cornell University任独立研究员,2024年晋升为助理教授(科研轨)。2025年作为独立PI加入中国药科大学生命科学与技术学院,并获得学校高层次人才计划支持。近年来以第一或通讯作者在Nature Biotechnology、Nature Communications等国际知名期刊发表多篇论文。热忱欢迎对课题组感兴趣的本科生,研究生和博士后加入实验室,一起探索免疫系统的奥秘。


研究方向

不同生理和病理状态下适应性免疫受体组的解码与挖掘

多组学工具解析与编程细胞信号转导

智能大分子与细胞药物设计


主持在研项目情况

国家高层次青年人才项目

中国药科大学兴药领军学者项目


近年代表性科研成果

Walseng, E. *, Wang, B. *, Yang, C., Patel, P., Zhao, C., Wu, H., Dall’Acqua, W., Mazor, Y., Conformation-selective instead of avidity-based binding to tumor associated antigen derived peptide-MHC enables targeting of pMHC low expressing cells by anti-pMHC/anti-CD3 T cell engager DuetMab, Front Immunol, 14, (2023)

Wang, X., Wang, K., Yu, M., Velluto, D., Hong, X., Wang, B., Chiu, A., Melero-Martin, J. M., Tomei, A. A., Ma, M., Engineered immunomodulatory accessory cells improve experimental allogeneic islet transplantation without immunosuppression, Science Advances, 8, eabn0071 (2022)

Wang, B.#, Chen, J., Caserto, J. S., Wang, X., Ma, M.#, An in situ hydrogel-mediated chemo-immunometabolic cancer therapy. Nature Communications, 13, 3821 (2022)

Chen, J.*, Wang, B.*#, Caserto, J. S., Shariati, K., Cao, P., Pan, Y., Xu, Q., Ma, M.#, Sustained Delivery of SARS-CoV-2 RBD Subunit Vaccine Using a High Affinity Injectable Hydrogel Scaffold. Adv Healthc Mater, 11, e2101714 (2022)

Liu, Q., Wang, X., Chiu, A., Liu, W., Fuchs, S., Wang, B., Wang, L. H., Flanders, J., Zhang, Y., Wang, K., Melero-Martin, J. M., Ma, M., A Zwitterionic Polyurethane Nanoporous Device with Low Foreign-Body Response for Islet Encapsulation, Adv Mater, 33, e2102852 (2021)

Wang, X., Maxwell, K. G., Wang, K., Bowers, D. T., Flanders, J. A., Liu, W., Wang, L. H., Liu, Q., Liu, C., Naji, A., Wang, Y., Wang, B., Chen, J., Ernst, A. U., Melero-Martin, J. M., Millman, J. R., Ma, M., A nanofibrous encapsulation device for safe delivery of insulin-producing cells to treat type 1 diabetes, Science Translational Medicine, 13, abb4601 (2021)

Dovedi, S. J., Elder, M. J., Yang, C., Sitnikova, S. I., Irving, L., Hansen, A., Hair, J., Jones, D. C., Hasani, S., Wang, B., Im, S. A., Tran, B., Subramaniam, D. S., Gainer, S. D., Vashisht, K., Lewis, A., Jin, X, Kentner, S., Mulgrew, K., Wang, Y., Overstreet, M. G., Dodgson, J., Wu, Y., Palazon, A., Morrow, M., Rainey, G. J., Browne, G. J., Neal, F., Murray, T. V., Toloczko, A. D., Dall’Acqua, W., Achour, I., Freeman, D. J., Wilkinson, R. W., Mazor, Y., Design and efficacy of a monovalent bispecific PD-1/CTLA-4 antibody that enhances CTLA-4 blockade on PD-1+ activated T cells, Cancer Discovery, 11, 1100-1117 (2021)

Wang, B., Yang C., Jin, X., Du, Q., Wu, H., Dall’Acqua, W., Mazor, Y., Regulation of antibody-mediated complement-dependent cytotoxicity by modulating the intrinsic affinity and binding valency of IgG for target antigen, mAbs, 12, 1690959 (2020)

Wang, B., DeKosky, B. J., Timm, M. R., Lee, J., Normandin, E., Misasi, J., Kong, R., McDaniel, J. R., Delidakis, G., Leigh, K. E., Niezold, T, Choi, C. W., Viox, E. G., Fahad, A., Cagigi, A., Ploquin, A., Leung, K., Yang, E. S., Kong, W. P., Voss, W. N., Schmidt, A. G., Moody, M. A., Ambrozak, D. R., Henry, A. R., Laboune, F., Ledgerwood, J. E., Graham, B. S., Connors, M., Douek, D. C., Sullivan, N. J., Ellington A. D., Mascola, J. R., Georgiou, G., Functional interrogation and mining of natively paired human VH:VL antibody repertoires, Nature Biotechnology, 36, 152-155 (2018)

Tack, D. S., Ellefson, J. W., Thyer, R., Wang, B., Gollihar, J., Forster, M. T., Ellington, A. D., Addicting diverse bacteria to a noncanonical amino acid, Nature Chemical Biolology, 12, 138-140 (2016)