药物合成生物学，生物催化，酶工程，新酶的发现与酶工程改造，绿色生物制造，多酶级联反应

1． 国家自然科学基金青年项目，82003627，2021-2023，主持

2． 江苏省自然科学基金青年项目，BK20200565，2020-2023，主持

1. Zhang, J., Grandi E., Fu H., Saravanan T., Bothof L., Tepper P.G., Thunnissen A.-M. W.H. & Poelarends, G.J., “Enantioselective synthesis of chiral synthons for artificial dipeptide sweeteners catalyzed by an engineered C-N lyase”, Angew. Chem. Int. Ed., 59, 429-435 (2020).

2. Zhang, J., Fu, H., Tepper, P.G. & Poelarends, G.J., “Biocatalytic enantioselective hydroaminations for production of N-cycloalkyl-substituted L-aspartic acids using two C-N lyases”, Adv. Synth. Catal., 361, 2433-2437 (2019).

3. Fu, H.*, Zhang, J.*, Saifuddin, M.*, Cruiming, G., Tepper, P.G. & Poelarends, G.J., “Chemoenzymatic asymmetric synthesis of the metallo-β-lactamase inhibitor aspergillomarasmine A and related aminocarboxylic acids”, Nat. Catal., 1, 186-191 (2018).

4. Fu, H., Zhang, J., Tepper, P.G., Bunch, L., Jensen, A. & Poelarends, G.J., “Chemoenzymatic synthesis and pharmacological characterization of functionalized aspartate analogues as novel excitatory amino acid transporter inhibitors”, J. Med. Chem., 61, 7741-7753 (2018).

5. Zhang, J., Tao, S., Zhang, B., Wu, X. & Chen, Y., “A Microparticle-Based Strategy for Controlled Release of Substrate for the Biocatalytic Preparation of L-Homophenylalanine”, ACS Catal., 4 1584-1587 (2014).